‘Cooking’ A Vaccine
- SciSoup
- March 1, 2021
MELANIE KRAUSE
Multiple COVID-19 vaccines have been released across the world, now the biggest challenge for public health officials is to convince the people to actually get the vaccine. Here, Melanie Krause, Postdoctoral Fellow at European Molecular Biology Laboratory (EMBL) Heidelberg, Germany, shares how she has convinced her grandmother with an interesting sketch & cooking analogy.
My grandmother didn’t want to get vaccinated with ‘strange new mRNA stuff’. I explained it with a sketch & cooking analogy. She’s now been vaccinated with the BionTech vaccine. I thought this might be useful for others who know vaccine skeptics, too.
Imagine you have a ginormous cook book in your living room. It contains all recipes you know. Unfortunately, it is too big to carry around and move into the kitchen. Thus, every time you want to cook something you need to write a copy of the recipe on a piece for paper and carry it into the kitchen where you have all the ingredients to make the dish. Now you can cook whatever recipe you decided to copy.. in our case milk soup (my grandmothers choice.. I don’t know why you would pick that out of all the delicious foods out there.. it’s like being able to make every protein there is but you waste your time on collagen).
Similarly, the nucleus in every one of our cells contains the DNA, that has all the recipes to make very protein our cells need. To make those proteins the cell makes a copy of the instruction for the protein it wants to make and sends it to the cytoplasm.. the place where proteins are made. This copy is called messenger RNA or mRNA. This mRNA is now used as manual or recipe to make a protein.. let’s say collagen.
Now envision you are standing in your kitchen and someone slides a recipe copy under the door. This recipe could be for a rice curry. You can now cook this dish using the same ingredients and equipment you had at home anyway but this recipe copy won’t be part of your living room cookbook. It will just be a copy that eventually tears, get wet or won’t be usable for other reasons, so you can only make the curry dish as long as you have that copy.
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With the mRNA vaccine a recipe for the SARS-CoV-2 spike protein gets transported into some of your body cells. It doesn’t enter the nucleus and doesn’t change the DNA because it’s just a copy (not the actual cookbook). The cell then makes the spike protein as long as the mRNA can serve as instruction manual. When it degrades (which happens eventually as mRNA is not very stable in the long run) the cell no longer makes spike proteins. The proteins it has made however can now be displayed on the cell surface so that immune cells can ‘study’ the shape, structure and size for the protein so that once an actual SARS-CoV-2 virus comes into the body they are prepared to attack and eliminate the virus.
Melanie Krause has done PhD in Cell Biology of Infection and currently working as Postdoctoral Fellow at European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.



