{"id":2169,"date":"2021-03-28T13:09:00","date_gmt":"2021-03-28T13:09:00","guid":{"rendered":"https:\/\/scisoup.org\/in\/?p=2169"},"modified":"2026-07-14T13:15:54","modified_gmt":"2026-07-14T13:15:54","slug":"scientists-untangle-brain-disorder-mystery-impacting-therapeutic-enigma","status":"publish","type":"post","link":"https:\/\/scisoup.org\/in\/2021\/03\/28\/scientists-untangle-brain-disorder-mystery-impacting-therapeutic-enigma\/","title":{"rendered":"Scientists Untangle Brain Disorder Mystery Impacting Therapeutic Enigma"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2169\" class=\"elementor elementor-2169\">\n\t\t\t\t<div class=\"elementor-element elementor-element-40ccaed e-flex e-con-boxed e-con e-parent\" data-id=\"40ccaed\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element 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heateor_sss_no_fill\" stroke=\"#fff\" stroke-width=\"2\" fill=\"none\" d=\"M 11.579798566743314 24.396926207859085 A 10 10 0 1 0 6.808479557110079 20.73576436351046\"><\/path><path d=\"M 7 19 l -1 6 l 6 -1\" class=\"heateor_sss_no_fill heateor_sss_svg_stroke\" stroke=\"#fff\" stroke-width=\"2\" fill=\"none\"><\/path><path d=\"M 10 10 q -1 8 8 11 c 5 -1 0 -6 -1 -3 q -4 -3 -5 -5 c 4 -2 -1 -5 -1 -4\" fill=\"#fff\"><\/path><\/svg><\/span><\/a><\/div><div class=\"heateorSssClear\"><\/div><\/div><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-49601ccc elementor-widget elementor-widget-image\" data-id=\"49601ccc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"614\" src=\"https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/07\/28-03-2021-1024x614.png\" class=\"attachment-large size-large wp-image-2170\" alt=\"\" srcset=\"https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/07\/28-03-2021-1024x614.png 1024w, https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/07\/28-03-2021-300x180.png 300w, https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/07\/28-03-2021-768x461.png 768w, https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/07\/28-03-2021.png 1250w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54ac9b4e elementor-widget elementor-widget-text-editor\" data-id=\"54ac9b4e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>RAJESH D. GUNAGE<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6eb9ae40 elementor-widget elementor-widget-heading\" data-id=\"6eb9ae40\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">New study provides a roadmap for future drug screening to exclusively target IDR or LSM part of ATXN2 protein, leaving the rest of the protein function unaffected using the fly model of neurodegeneration to improve ailing brain function.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5a0e4fe5 elementor-widget elementor-widget-text-editor\" data-id=\"5a0e4fe5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><b><strong>A<\/strong><\/b><span style=\"font-weight: 400;\">\u00a0good life requires a healthy brain that in turn controls the rest of the body functions. Unfortunately, in neurodegenerative disorders such as Alzheimer\u2019s disease and Amyotrophic Lateral Sclerosis (ALS), an individual progressively loses brain cells called \u201cneurons\u201d. This has direct effects on coordination and memory &#8211; making a simple task such as drinking a cup of tea very challenging &#8211; causing distress.<\/span><br style=\"font-weight: 400;\" \/><br style=\"font-weight: 400;\" \/><span style=\"font-weight: 400;\">Using the Drosophila, the fruit fly, as a model, a group of scientists has provided new insights for the development of therapeutics for targeting a gene, Ataxin-2. Mutation in human Ataxin-2 is linked to brain diseases such as spinocerebellar ataxia. The results of this collaborative study, done by Dr. Baskar Bakthavachalu (TIGS Centre at inStem, Bangalore and IIT, Mandi) and Dr. Mani Ramaswami (Trinity College, Dublin), have been published in the journal\u00a0<\/span><em style=\"font-weight: 400;\">eLife<\/em><span style=\"font-weight: 400;\">.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ce7c0be elementor-widget elementor-widget-image\" data-id=\"ce7c0be\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1024\" height=\"481\" src=\"https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/07\/28-03-2021-01-1024x481.png\" class=\"attachment-large size-large wp-image-2172\" alt=\"\" srcset=\"https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/07\/28-03-2021-01-1024x481.png 1024w, https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/07\/28-03-2021-01-300x141.png 300w, https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/07\/28-03-2021-01-768x361.png 768w, https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/07\/28-03-2021-01.png 1250w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-306ec9f elementor-widget elementor-widget-text-editor\" data-id=\"306ec9f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>In this study, Dr. Amanjot Singh and Dr. Joern Hulsmeier (lead authors) have used powerful fly genetics tricks to identify a key region of the Ataxin-2 protein called IDR (Intrinsically Disordered Region). The authors find that IDR is important for regulated protein production in healthy neurons. IDR of Ataxin-2 binds to RNA through the process of RNA tail grabbing to fine-tune protein production. What came as a real surprise to the team was that the same part is also responsible for causing disorders. Mutations in IDR cause failure in the timely release of RNA, resulting in protein tangles much like cooked noodles in a bowl.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7898d21e e-con-full e-flex e-con e-child\" data-id=\"7898d21e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-50989a36 e-con-full e-flex e-con e-child\" data-id=\"50989a36\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-191f8c6e e-con-full e-flex e-con e-child\" data-id=\"191f8c6e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2e1e3a2f elementor-widget elementor-widget-text-editor\" data-id=\"2e1e3a2f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"comment vl\"><div class=\"comment vl\"><div class=\"comment vl\"><p>\u201cPhysician Dr. Noshir Hormusjee Wadia first described the role of Ataxin-2 mutation in a cohort of Indian patients with an eye movement disorder. Dr. Bakthavachalu foresees that findings from the current study might help to design a small drug molecule that could alleviate such disease.<\/p><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6d2bc02a elementor-widget elementor-widget-text-editor\" data-id=\"6d2bc02a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>These tangles create gridlocks in the neurons, and this leads to neuronal death. Authors propose that stopping this process at an early stage through Ataxin-2 based intervention can save millions of lives.<br \/><br \/>IDR\u2019s tangling is controlled by the Lsm domain, another region of Ataxin-2 protein. In the diseased condition, the balance sways more towards IDR. Authors propose that strengthening Lsm function can be an alternative strategy to develop new treatments for neurodegenerative disease.<br \/><br \/>In summary, this study provides a roadmap for future drug screening to exclusively target IDR or LSM part of ATXN2, leaving the rest of the protein function unaffected using the fly model of neurodegeneration to improve ailing brain function.<br \/><br \/>The research team included Amanjot Singh, Joern Hulsmeier, Arvind Reddy Kandi, Sai Shruti Pothapragada, Jens Hillebrand, Arnas Petrauskas, Khushboo Agrawal, Krishnan RT, Devasena Thiagarajan, Deepa Jayaprakashappa, K. VijayRaghavan, Mani Ramaswami, and Baskar Bakthavachalu.<br \/><br \/>The study was funded by DST-SERB, Wellcome Trust\/DBT India Alliance, and Science Foundation Ireland.<br \/><br \/><b>Guest Editors<\/b>\u00a0&#8211; Dr. Madhumala K. S. (Geisel School of Medicine at Dartmouth, USA) and Dr. Aanchal Bhatia (Brandeis University, USA)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1ff7d24e elementor-widget elementor-widget-text-editor\" data-id=\"1ff7d24e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>Journal Reference:<\/strong><br \/><a href=\"https:\/\/elifesciences.org\/articles\/60326\" target=\"_blank\" rel=\"noopener\">Antagonistic roles for Ataxin-2 structured and disordered domains in RNP condensation<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3228f60c e-con-full e-flex e-con e-child\" data-id=\"3228f60c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3a9ee9d1 section-title-style-style2 title-three-line meta-visibility-show title_position_default 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line-left\"><\/span>\n\t\t\t<h2 class='tpg-widget-heading'>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<span>\n\t\t\t\t\t\tTOP STORIES\t\t\t\t\t<\/span>\n\t\t\t\t\t\n\t\t\t\t\t\t\t<\/h2>\t\t\t<span class=\"tpg-widget-heading-line line-right\"><\/span>\n\n\t\t\t\n\t\t<\/div>\n\n\t\t\n\t\t            <\/div>\n\n            <div data-title=\"Loading ...\" class=\"rt-row rt-content-loader list-layout1 tpg-even list-behaviour list-layout-wrapper\">\n\t\t\t\t\n<div class=\"rt-col-md-12 rt-col-sm-12 rt-col-xs-12 default rt-list-item rt-grid-item\" data-id=\"2211\">\n\t<div class=\"rt-holder tpg-post-holder \">\n\t\t<div class=\"rt-detail rt-el-content-wrapper\">\n\t\t\t\t\t\t\t<div class=\"rt-img-holder tpg-el-image-wrap has-thumbnail\">\n\t\t\t\t\t<a data-id=\"2211\" href=\"https:\/\/scisoup.org\/in\/2026\/07\/15\/how-faulty-rna-processing-alerts-cells-to-infection\/\" class=\"tpg-post-link\" target=\"_self\">\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/07\/JSingh-150x150.png\"\n\t\t\t\t\t\t\t class=\"rt-img-responsive\"\n\t\t\t\t\t\t\t width=\"150\"\n\t\t\t\t\t\t\t height=\"150\"\n\t\t\t\t\t\t\t alt=\"How Faulty RNA Processing Alerts Cells to Infection\">\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t<\/a>\n\t\t\t\t<div class=\"overlay grid-hover-content\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t<div class=\"post-right-content\">\n\t\t\t\t<div class=\"entry-title-wrapper\"><h3 class=\"entry-title\"><a data-id=\"2211\" href=\"https:\/\/scisoup.org\/in\/2026\/07\/15\/how-faulty-rna-processing-alerts-cells-to-infection\/\" class=\"tpg-post-link\" target=\"_self\">How Faulty RNA Processing Alerts Cells to Infection<\/a><\/h3><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"post-meta-tags rt-el-post-meta\">\n\t\t\t\t\t\t\t\t\t<span class=\"date\">\n\t\t\t\t<i class=\"tpg-flaticon-calendar \"><\/i>\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/scisoup.org\/in\/2026\/07\/15\/\">\n\t\t\t\t\tJuly 15, 2026\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"categories-links\">\n\t\t\t\t<i class=\"tpg-flaticon-folder \"><\/i><a class=\"articles\" href=\"https:\/\/scisoup.org\/in\/category\/articles\/\">Articles<\/a><span class=\"rt-separator\">,<\/span><a class=\"latest\" href=\"https:\/\/scisoup.org\/in\/category\/latest\/\">Latest<\/a><span class=\"rt-separator\">,<\/span><a class=\"recent-posts\" href=\"https:\/\/scisoup.org\/in\/category\/recent-posts\/\">Recent Posts<\/a>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div class=\"rt-col-md-12 rt-col-sm-12 rt-col-xs-12 default rt-list-item rt-grid-item\" data-id=\"2042\">\n\t<div class=\"rt-holder tpg-post-holder \">\n\t\t<div class=\"rt-detail rt-el-content-wrapper\">\n\t\t\t\t\t\t\t<div class=\"rt-img-holder tpg-el-image-wrap has-thumbnail\">\n\t\t\t\t\t<a data-id=\"2042\" href=\"https:\/\/scisoup.org\/in\/2026\/07\/12\/scisoup-lab-stories-conversations-with-stem-leaders\/\" class=\"tpg-post-link\" target=\"_self\">\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/07\/SCISOUP-FLYER-BANNER-150x150.png\"\n\t\t\t\t\t\t\t class=\"rt-img-responsive\"\n\t\t\t\t\t\t\t width=\"150\"\n\t\t\t\t\t\t\t height=\"150\"\n\t\t\t\t\t\t\t alt=\"SciSoup Lab Stories: Conversations with STEM Leaders\">\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t<\/a>\n\t\t\t\t<div class=\"overlay grid-hover-content\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t<div class=\"post-right-content\">\n\t\t\t\t<div class=\"entry-title-wrapper\"><h3 class=\"entry-title\"><a data-id=\"2042\" href=\"https:\/\/scisoup.org\/in\/2026\/07\/12\/scisoup-lab-stories-conversations-with-stem-leaders\/\" class=\"tpg-post-link\" target=\"_self\">SciSoup Lab Stories: Conversations with STEM Leaders<\/a><\/h3><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"post-meta-tags rt-el-post-meta\">\n\t\t\t\t\t\t\t\t\t<span class=\"date\">\n\t\t\t\t<i class=\"tpg-flaticon-calendar \"><\/i>\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/scisoup.org\/in\/2026\/07\/12\/\">\n\t\t\t\t\tJuly 12, 2026\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"categories-links\">\n\t\t\t\t<i class=\"tpg-flaticon-folder \"><\/i><a class=\"articles\" href=\"https:\/\/scisoup.org\/in\/category\/articles\/\">Articles<\/a><span class=\"rt-separator\">,<\/span><a class=\"lab-stories\" href=\"https:\/\/scisoup.org\/in\/category\/lab-stories\/\">Lab Stories<\/a><span class=\"rt-separator\">,<\/span><a class=\"latest\" href=\"https:\/\/scisoup.org\/in\/category\/latest\/\">Latest<\/a><span class=\"rt-separator\">,<\/span><a class=\"spotlight\" href=\"https:\/\/scisoup.org\/in\/category\/spotlight\/\">Spotlight<\/a>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div class=\"rt-col-md-12 rt-col-sm-12 rt-col-xs-12 default rt-list-item rt-grid-item\" data-id=\"1954\">\n\t<div class=\"rt-holder tpg-post-holder \">\n\t\t<div class=\"rt-detail rt-el-content-wrapper\">\n\t\t\t\t\t\t\t<div class=\"rt-img-holder tpg-el-image-wrap has-thumbnail\">\n\t\t\t\t\t<a data-id=\"1954\" href=\"https:\/\/scisoup.org\/in\/2026\/07\/02\/science-beyond-boundaries-inspiring-ideas-from-the-37th-mid-year-meeting-of-the-indian-academy-of-sciences\/\" class=\"tpg-post-link\" target=\"_self\">\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/07\/Special_and_Public_Lecture_MYM_2026-4-150x150.png\"\n\t\t\t\t\t\t\t class=\"rt-img-responsive\"\n\t\t\t\t\t\t\t width=\"150\"\n\t\t\t\t\t\t\t height=\"150\"\n\t\t\t\t\t\t\t alt=\"Science Beyond Boundaries: Inspiring Ideas from the 37th Mid-Year Meeting of the Indian Academy of Sciences\">\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t<\/a>\n\t\t\t\t<div class=\"overlay grid-hover-content\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t<div class=\"post-right-content\">\n\t\t\t\t<div class=\"entry-title-wrapper\"><h3 class=\"entry-title\"><a data-id=\"1954\" href=\"https:\/\/scisoup.org\/in\/2026\/07\/02\/science-beyond-boundaries-inspiring-ideas-from-the-37th-mid-year-meeting-of-the-indian-academy-of-sciences\/\" class=\"tpg-post-link\" target=\"_self\">Science Beyond Boundaries: Inspiring Ideas from the 37th Mid-Year Meeting of the Indian Academy of Sciences<\/a><\/h3><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"post-meta-tags rt-el-post-meta\">\n\t\t\t\t\t\t\t\t\t<span class=\"date\">\n\t\t\t\t<i class=\"tpg-flaticon-calendar \"><\/i>\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/scisoup.org\/in\/2026\/07\/02\/\">\n\t\t\t\t\tJuly 2, 2026\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"categories-links\">\n\t\t\t\t<i class=\"tpg-flaticon-folder \"><\/i><a class=\"articles\" href=\"https:\/\/scisoup.org\/in\/category\/articles\/\">Articles<\/a><span class=\"rt-separator\">,<\/span><a class=\"recent-posts\" href=\"https:\/\/scisoup.org\/in\/category\/recent-posts\/\">Recent Posts<\/a>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div class=\"rt-col-md-12 rt-col-sm-12 rt-col-xs-12 default rt-list-item rt-grid-item\" data-id=\"1945\">\n\t<div class=\"rt-holder tpg-post-holder \">\n\t\t<div class=\"rt-detail rt-el-content-wrapper\">\n\t\t\t\t\t\t\t<div class=\"rt-img-holder tpg-el-image-wrap has-thumbnail\">\n\t\t\t\t\t<a data-id=\"1945\" href=\"https:\/\/scisoup.org\/in\/2026\/07\/02\/ultrasound-mechanostimulation-shows-promise-in-selectively-targeting-oral-cancer-cells\/\" class=\"tpg-post-link\" target=\"_self\">\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/07\/Ultrasound-cancer-cells2_Siddhesh-Saigaonkar-150x150.jpeg\"\n\t\t\t\t\t\t\t class=\"rt-img-responsive\"\n\t\t\t\t\t\t\t width=\"150\"\n\t\t\t\t\t\t\t height=\"150\"\n\t\t\t\t\t\t\t alt=\"Ultrasound Mechanostimulation Shows Promise In Selectively Targeting Oral Cancer Cells\">\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t<\/a>\n\t\t\t\t<div class=\"overlay grid-hover-content\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t<div class=\"post-right-content\">\n\t\t\t\t<div class=\"entry-title-wrapper\"><h3 class=\"entry-title\"><a data-id=\"1945\" href=\"https:\/\/scisoup.org\/in\/2026\/07\/02\/ultrasound-mechanostimulation-shows-promise-in-selectively-targeting-oral-cancer-cells\/\" class=\"tpg-post-link\" target=\"_self\">Ultrasound Mechanostimulation Shows Promise In Selectively Targeting Oral Cancer Cells<\/a><\/h3><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"post-meta-tags rt-el-post-meta\">\n\t\t\t\t\t\t\t\t\t<span class=\"date\">\n\t\t\t\t<i class=\"tpg-flaticon-calendar \"><\/i>\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/scisoup.org\/in\/2026\/07\/02\/\">\n\t\t\t\t\tJuly 2, 2026\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"categories-links\">\n\t\t\t\t<i class=\"tpg-flaticon-folder \"><\/i><a class=\"articles\" href=\"https:\/\/scisoup.org\/in\/category\/articles\/\">Articles<\/a><span class=\"rt-separator\">,<\/span><a class=\"latest\" href=\"https:\/\/scisoup.org\/in\/category\/latest\/\">Latest<\/a>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div class=\"rt-col-md-12 rt-col-sm-12 rt-col-xs-12 default rt-list-item rt-grid-item\" data-id=\"1936\">\n\t<div class=\"rt-holder tpg-post-holder \">\n\t\t<div class=\"rt-detail rt-el-content-wrapper\">\n\t\t\t\t\t\t\t<div class=\"rt-img-holder tpg-el-image-wrap has-thumbnail\">\n\t\t\t\t\t<a data-id=\"1936\" href=\"https:\/\/scisoup.org\/in\/2026\/06\/28\/3d-printed-silk-implant-regenerates-cartilage-in-osteoarthritic-rat-knees\/\" class=\"tpg-post-link\" target=\"_self\">\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/06\/OA-150x150.png\"\n\t\t\t\t\t\t\t class=\"rt-img-responsive\"\n\t\t\t\t\t\t\t width=\"150\"\n\t\t\t\t\t\t\t height=\"150\"\n\t\t\t\t\t\t\t alt=\"3D-Printed Silk Implant Regenerates Cartilage In Osteoarthritic Rat Knees\">\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t<\/a>\n\t\t\t\t<div class=\"overlay grid-hover-content\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t<div class=\"post-right-content\">\n\t\t\t\t<div class=\"entry-title-wrapper\"><h3 class=\"entry-title\"><a data-id=\"1936\" href=\"https:\/\/scisoup.org\/in\/2026\/06\/28\/3d-printed-silk-implant-regenerates-cartilage-in-osteoarthritic-rat-knees\/\" class=\"tpg-post-link\" target=\"_self\">3D-Printed Silk Implant Regenerates Cartilage In Osteoarthritic Rat Knees<\/a><\/h3><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"post-meta-tags rt-el-post-meta\">\n\t\t\t\t\t\t\t\t\t<span class=\"date\">\n\t\t\t\t<i class=\"tpg-flaticon-calendar \"><\/i>\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/scisoup.org\/in\/2026\/06\/28\/\">\n\t\t\t\t\tJune 28, 2026\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"categories-links\">\n\t\t\t\t<i class=\"tpg-flaticon-folder \"><\/i><a class=\"articles\" href=\"https:\/\/scisoup.org\/in\/category\/articles\/\">Articles<\/a><span class=\"rt-separator\">,<\/span><a class=\"lab-stories\" href=\"https:\/\/scisoup.org\/in\/category\/lab-stories\/\">Lab Stories<\/a><span class=\"rt-separator\">,<\/span><a class=\"latest\" href=\"https:\/\/scisoup.org\/in\/category\/latest\/\">Latest<\/a><span class=\"rt-separator\">,<\/span><a class=\"recent-posts\" href=\"https:\/\/scisoup.org\/in\/category\/recent-posts\/\">Recent Posts<\/a>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div class=\"rt-col-md-12 rt-col-sm-12 rt-col-xs-12 default rt-list-item rt-grid-item\" data-id=\"1877\">\n\t<div class=\"rt-holder tpg-post-holder \">\n\t\t<div class=\"rt-detail rt-el-content-wrapper\">\n\t\t\t\t\t\t\t<div class=\"rt-img-holder tpg-el-image-wrap has-thumbnail\">\n\t\t\t\t\t<a data-id=\"1877\" href=\"https:\/\/scisoup.org\/in\/2026\/06\/13\/muscle-protein-helps-control-blood-sugar-revealing-new-link-to-diabetes\/\" class=\"tpg-post-link\" target=\"_self\">\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/06\/Sam-Mathew-Research-team-150x150.jpg\"\n\t\t\t\t\t\t\t class=\"rt-img-responsive\"\n\t\t\t\t\t\t\t width=\"150\"\n\t\t\t\t\t\t\t height=\"150\"\n\t\t\t\t\t\t\t alt=\"Muscle protein helps control blood sugar, revealing new link to diabetes\">\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t<\/a>\n\t\t\t\t<div class=\"overlay grid-hover-content\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t<div class=\"post-right-content\">\n\t\t\t\t<div class=\"entry-title-wrapper\"><h3 class=\"entry-title\"><a data-id=\"1877\" href=\"https:\/\/scisoup.org\/in\/2026\/06\/13\/muscle-protein-helps-control-blood-sugar-revealing-new-link-to-diabetes\/\" class=\"tpg-post-link\" target=\"_self\">Muscle protein helps control blood sugar, revealing new link to diabetes<\/a><\/h3><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"post-meta-tags rt-el-post-meta\">\n\t\t\t\t\t\t\t\t\t<span class=\"date\">\n\t\t\t\t<i class=\"tpg-flaticon-calendar \"><\/i>\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/scisoup.org\/in\/2026\/06\/13\/\">\n\t\t\t\t\tJune 13, 2026\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"categories-links\">\n\t\t\t\t<i class=\"tpg-flaticon-folder \"><\/i><a class=\"articles\" href=\"https:\/\/scisoup.org\/in\/category\/articles\/\">Articles<\/a><span class=\"rt-separator\">,<\/span><a class=\"lab-stories\" href=\"https:\/\/scisoup.org\/in\/category\/lab-stories\/\">Lab Stories<\/a><span class=\"rt-separator\">,<\/span><a class=\"latest\" href=\"https:\/\/scisoup.org\/in\/category\/latest\/\">Latest<\/a><span class=\"rt-separator\">,<\/span><a class=\"recent-posts\" href=\"https:\/\/scisoup.org\/in\/category\/recent-posts\/\">Recent Posts<\/a>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div class=\"rt-col-md-12 rt-col-sm-12 rt-col-xs-12 default rt-list-item rt-grid-item\" data-id=\"1329\">\n\t<div class=\"rt-holder tpg-post-holder \">\n\t\t<div class=\"rt-detail rt-el-content-wrapper\">\n\t\t\t\t\t\t\t<div class=\"rt-img-holder tpg-el-image-wrap has-thumbnail\">\n\t\t\t\t\t<a data-id=\"1329\" href=\"https:\/\/scisoup.org\/in\/2025\/10\/08\/read-more-write-more-a-realistic-guide-to-academic-writing\/\" class=\"tpg-post-link\" target=\"_self\">\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/05\/08102025-150x150.png\"\n\t\t\t\t\t\t\t class=\"rt-img-responsive\"\n\t\t\t\t\t\t\t width=\"150\"\n\t\t\t\t\t\t\t height=\"150\"\n\t\t\t\t\t\t\t alt=\"Read More, Write More: A Realistic Guide to Academic Writing\">\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t<\/a>\n\t\t\t\t<div class=\"overlay grid-hover-content\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t<div class=\"post-right-content\">\n\t\t\t\t<div class=\"entry-title-wrapper\"><h3 class=\"entry-title\"><a data-id=\"1329\" href=\"https:\/\/scisoup.org\/in\/2025\/10\/08\/read-more-write-more-a-realistic-guide-to-academic-writing\/\" class=\"tpg-post-link\" target=\"_self\">Read More, Write More: A Realistic Guide to Academic Writing<\/a><\/h3><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"post-meta-tags rt-el-post-meta\">\n\t\t\t\t\t\t\t\t\t<span class=\"date\">\n\t\t\t\t<i class=\"tpg-flaticon-calendar \"><\/i>\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/scisoup.org\/in\/2025\/10\/08\/\">\n\t\t\t\t\tOctober 8, 2025\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"categories-links\">\n\t\t\t\t<i 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src=\"https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/03\/03092025-150x150.png\"\n\t\t\t\t\t\t\t class=\"rt-img-responsive\"\n\t\t\t\t\t\t\t width=\"150\"\n\t\t\t\t\t\t\t height=\"150\"\n\t\t\t\t\t\t\t alt=\"Plants Rebuild Roots Using Geometry, Not Just Genes: Study\">\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t<\/a>\n\t\t\t\t<div class=\"overlay grid-hover-content\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t<div class=\"post-right-content\">\n\t\t\t\t<div class=\"entry-title-wrapper\"><h3 class=\"entry-title\"><a data-id=\"1339\" href=\"https:\/\/scisoup.org\/in\/2025\/09\/03\/plants-rebuild-roots-using-geometry-not-just-genes-study\/\" class=\"tpg-post-link\" target=\"_self\">Plants Rebuild Roots Using Geometry, Not Just Genes: Study<\/a><\/h3><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"post-meta-tags rt-el-post-meta\">\n\t\t\t\t\t\t\t\t\t<span class=\"date\">\n\t\t\t\t<i class=\"tpg-flaticon-calendar \"><\/i>\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/scisoup.org\/in\/2025\/09\/03\/\">\n\t\t\t\t\tSeptember 3, 2025\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"categories-links\">\n\t\t\t\t<i class=\"tpg-flaticon-folder \"><\/i><a class=\"articles\" href=\"https:\/\/scisoup.org\/in\/category\/articles\/\">Articles<\/a><span class=\"rt-separator\">,<\/span><a class=\"latest\" href=\"https:\/\/scisoup.org\/in\/category\/latest\/\">Latest<\/a><span class=\"rt-separator\">,<\/span><a class=\"recent-posts\" href=\"https:\/\/scisoup.org\/in\/category\/recent-posts\/\">Recent Posts<\/a>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div class=\"rt-col-md-12 rt-col-sm-12 rt-col-xs-12 default rt-list-item rt-grid-item\" data-id=\"1321\">\n\t<div class=\"rt-holder tpg-post-holder \">\n\t\t<div class=\"rt-detail rt-el-content-wrapper\">\n\t\t\t\t\t\t\t<div class=\"rt-img-holder tpg-el-image-wrap has-thumbnail\">\n\t\t\t\t\t<a data-id=\"1321\" href=\"https:\/\/scisoup.org\/in\/2025\/05\/06\/scientists-uncover-unusual-cell-division-behind-glioblastomas-deadly-comeback-3\/\" class=\"tpg-post-link\" target=\"_self\">\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/01\/06052025-150x150.png\"\n\t\t\t\t\t\t\t class=\"rt-img-responsive\"\n\t\t\t\t\t\t\t width=\"150\"\n\t\t\t\t\t\t\t height=\"150\"\n\t\t\t\t\t\t\t alt=\"Scientists Uncover Unusual Cell Division Behind Glioblastoma\u2019s Deadly Comeback\">\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t<\/a>\n\t\t\t\t<div class=\"overlay grid-hover-content\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t<div class=\"post-right-content\">\n\t\t\t\t<div class=\"entry-title-wrapper\"><h3 class=\"entry-title\"><a data-id=\"1321\" href=\"https:\/\/scisoup.org\/in\/2025\/05\/06\/scientists-uncover-unusual-cell-division-behind-glioblastomas-deadly-comeback-3\/\" class=\"tpg-post-link\" target=\"_self\">Scientists Uncover Unusual Cell Division Behind Glioblastoma\u2019s Deadly Comeback<\/a><\/h3><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"post-meta-tags rt-el-post-meta\">\n\t\t\t\t\t\t\t\t\t<span class=\"date\">\n\t\t\t\t<i class=\"tpg-flaticon-calendar \"><\/i>\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/scisoup.org\/in\/2025\/05\/06\/\">\n\t\t\t\t\tMay 6, 2025\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"categories-links\">\n\t\t\t\t<i class=\"tpg-flaticon-folder \"><\/i><a class=\"articles\" href=\"https:\/\/scisoup.org\/in\/category\/articles\/\">Articles<\/a><span class=\"rt-separator\">,<\/span><a class=\"latest\" href=\"https:\/\/scisoup.org\/in\/category\/latest\/\">Latest<\/a><span class=\"rt-separator\">,<\/span><a class=\"recent-posts\" href=\"https:\/\/scisoup.org\/in\/category\/recent-posts\/\">Recent Posts<\/a>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n            <\/div>\n\n\t\t\t\n        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GUNAGE New study provides a roadmap [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2170,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[14,1],"tags":[],"class_list":["post-2169","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-articles","category-uncategorized"],"rttpg_featured_image_url":{"full":["https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/07\/28-03-2021.png",1250,750,false],"landscape":["https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/07\/28-03-2021.png",1250,750,false],"portraits":["https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/07\/28-03-2021.png",1250,750,false],"thumbnail":["https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/07\/28-03-2021-150x150.png",150,150,true],"medium":["https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/07\/28-03-2021-300x180.png",300,180,true],"large":["https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/07\/28-03-2021-1024x614.png",1024,614,true],"1536x1536":["https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/07\/28-03-2021.png",1250,750,false],"2048x2048":["https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/07\/28-03-2021.png",1250,750,false]},"rttpg_author":{"display_name":"SciSoup","author_link":"https:\/\/scisoup.org\/in\/author\/admin\/"},"rttpg_comment":0,"rttpg_category":"<a href=\"https:\/\/scisoup.org\/in\/category\/articles\/\" rel=\"category tag\">Articles<\/a> <a href=\"https:\/\/scisoup.org\/in\/category\/uncategorized\/\" rel=\"category tag\">Uncategorized<\/a>","rttpg_excerpt":"Scientists Untangle Brain Disorder Mystery Impacting Therapeutic Enigma SciSoup March 28, 2021 RAJESH D. 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