{"id":1815,"date":"2018-10-16T05:35:39","date_gmt":"2018-10-16T05:35:39","guid":{"rendered":"https:\/\/scisoup.org\/in\/?p=1815"},"modified":"2026-06-15T07:02:55","modified_gmt":"2026-06-15T07:02:55","slug":"scientists-find-why-long-chain-lipids-accumulate-inside-brain-in-pharc-disorder","status":"publish","type":"post","link":"https:\/\/scisoup.org\/in\/2018\/10\/16\/scientists-find-why-long-chain-lipids-accumulate-inside-brain-in-pharc-disorder\/","title":{"rendered":"Scientists Find Why Long Chain Lipids Accumulate Inside Brain In PHARC Disorder"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"1815\" class=\"elementor elementor-1815\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7093e0de e-flex e-con-boxed e-con e-parent\" data-id=\"7093e0de\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-1e457c1b e-con-full e-flex e-con e-child\" data-id=\"1e457c1b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-290c62f0 elementor-widget elementor-widget-sina_post_title\" data-id=\"290c62f0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"sina_post_title.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h2 class=\"sina-post-title\">Scientists Find Why Long Chain Lipids Accumulate Inside Brain In PHARC Disorder<\/h2><!-- .sina-post-title -->\r\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6494e116 e-grid e-con-full e-con e-child\" data-id=\"6494e116\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-368790a4 e-con-full e-flex e-con e-child\" 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decoding=\"async\" width=\"730\" height=\"450\" src=\"https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/06\/16-10-2018.png\" class=\"attachment-large size-large wp-image-1816\" alt=\"\" srcset=\"https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/06\/16-10-2018.png 730w, https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/06\/16-10-2018-300x185.png 300w\" sizes=\"(max-width: 730px) 100vw, 730px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-229caa8e elementor-widget elementor-widget-text-editor\" data-id=\"229caa8e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>RATNESHWAR THAKUR<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-30d07bab e-grid-align-left elementor-widget__width-initial elementor-widget-mobile__width-initial elementor-shape-rounded elementor-grid-0 elementor-widget 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data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Study will help to better understand the pathology of PHARC and it might enable development of much-needed biomarkers, very long chain lipids, for better diagnostics.\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-697733c3 elementor-widget elementor-widget-text-editor\" data-id=\"697733c3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><b><strong>P<\/strong><\/b><span style=\"font-weight: 400;\">HARC is a rare genetic human neurological disorder caused by mutations to the Abhd12 gene, which encodes the integral membrane serine hydrolase enzyme ABHD12.<\/span><br style=\"font-weight: 400;\" \/><br style=\"font-weight: 400;\" \/><span style=\"font-weight: 400;\">Recent studies have shown that mice without ABHD12, murine model of PHARC, show increased concentrations of lyso-phosphatidylserine (lyso-PS) lipids in brains. Now Indian researchers, using mice model, have found the biochemical explanation for such very long chain lipids accumulation in the brain.<\/span><br style=\"font-weight: 400;\" \/><br style=\"font-weight: 400;\" \/><span style=\"font-weight: 400;\">Dr. Siddhesh S. Kamat\u2019s team at Indian Institute of Science Education and Research (IISER), Pune &#8211; have shown that the enzyme ABHD12 has a strong substrate preference for very long chain lipids which contains \u2265 C22 atoms.<\/span><br style=\"font-weight: 400;\" \/><br style=\"font-weight: 400;\" \/><span style=\"font-weight: 400;\">Researchers found the location of this enzyme (ABHD12) in the membrane of the endoplasmic reticulum, a cellular compartment, where virtually, all of the very long chain lipids are biosynthesized. The results of this study were published in \u2018The Journal of Biological Chemistry.\u2019<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5c3e527d e-con-full e-flex e-con e-child\" data-id=\"5c3e527d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-1ca50ec7 e-con-full e-flex e-con e-child\" data-id=\"1ca50ec7\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1455f31e e-con-full e-flex e-con e-child\" data-id=\"1455f31e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2347ec98 elementor-widget elementor-widget-text-editor\" data-id=\"2347ec98\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"comment vl\"><div class=\"comment vl\"><div class=\"comment vl\">\u201cWe first chemically synthesized a library of lipid substrates ranging from fatty acids C10 \u2013 C24 with different degrees of un-saturations. Next, we performed enzyme kinetics studies for this lipid library against recombinant human, and endogenous mouse brain ABHD12, and found in both cases that there is a preference for very long chain lipids,\u201d said Dr. Siddhesh S. Kamat.<br \/><br \/>\u201cOur study will help to better understand the pathology of PHARC and it might enable development of much-needed biomarkers (very long chain lipids) for better diagnostics for this condition,\u201d he added.<\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-142f97fb elementor-widget elementor-widget-text-editor\" data-id=\"142f97fb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>\u201cThis work is a classic illustration of the value of a biochemical approach in understanding what a clinically important protein actually does in cells. This biochemical characterization reveals a very broad substrate choice for this important protein, and also explains how cells can maintain an appropriate balance of long-chain lipid substrates. This can now be used to identify activators or inhibitors of this enzyme,\u201d commented Dr. Sunil Laxman from InStem, Bangalore, who was not associated with this study.<br \/><br \/>The research team included Alaumy Joshi, Minhaj Shaikh, Shubham Singh, Abinaya Rajendran, Amol Mhetre and Siddhesh S. Kamat from IISER Pune. This study was supported by Wellcome Trust DBT India Alliance and DST-FIST infrastructure development grant.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4e1616e9 elementor-widget elementor-widget-text-editor\" data-id=\"4e1616e9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>Journal Reference:<\/strong><br \/><a href=\"https:\/\/www.jbc.org\/content\/early\/2018\/09\/19\/jbc.RA118.005640.abstract\" target=\"_blank\" rel=\"noopener\">Biochemical characterization of the PHARC associated serine hydrolase ABHD12 reveals its preference for very long chain lipids<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6709c66e elementor-widget elementor-widget-text-editor\" data-id=\"6709c66e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>Disclaimer:<\/strong><br \/>SciSoup claims no competing interest. 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tpg-el-main-wrapper list-layout1-main \"\n             data-sc-id=\"elementor\"\n             id=\"rt-tpg-container-1173174584\"\n             data-layout=\"list-layout1\"\n             data-grid-style=\"tpg-even\"\n             data-el-settings=''\n             data-el-query=''\n             data-el-path=''\n        >\n\t\t\t            <div class='tpg-header-wrapper '>\n\t\t\t\t\n\t\t<div class=\"tpg-widget-heading-wrapper rt-clear heading-style2 \">\n\t\t\t<span class=\"tpg-widget-heading-line line-left\"><\/span>\n\t\t\t<h2 class='tpg-widget-heading'>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<span>\n\t\t\t\t\t\tTOP STORIES\t\t\t\t\t<\/span>\n\t\t\t\t\t\n\t\t\t\t\t\t\t<\/h2>\t\t\t<span class=\"tpg-widget-heading-line line-right\"><\/span>\n\n\t\t\t\n\t\t<\/div>\n\n\t\t\n\t\t            <\/div>\n\n            <div data-title=\"Loading ...\" class=\"rt-row rt-content-loader list-layout1 tpg-even list-behaviour list-layout-wrapper\">\n\t\t\t\t\n<div class=\"rt-col-md-12 rt-col-sm-12 rt-col-xs-12 default rt-list-item rt-grid-item\" data-id=\"1877\">\n\t<div class=\"rt-holder tpg-post-holder \">\n\t\t<div class=\"rt-detail rt-el-content-wrapper\">\n\t\t\t\t\t\t\t<div class=\"rt-img-holder tpg-el-image-wrap has-thumbnail\">\n\t\t\t\t\t<a data-id=\"1877\" href=\"https:\/\/scisoup.org\/in\/2026\/06\/13\/muscle-protein-helps-control-blood-sugar-revealing-new-link-to-diabetes\/\" class=\"tpg-post-link\" target=\"_self\">\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/06\/Sam-Mathew-Research-team-150x150.jpg\"\n\t\t\t\t\t\t\t class=\"rt-img-responsive\"\n\t\t\t\t\t\t\t width=\"150\"\n\t\t\t\t\t\t\t height=\"150\"\n\t\t\t\t\t\t\t alt=\"Muscle protein helps control blood sugar, revealing new link to diabetes\">\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t<\/a>\n\t\t\t\t<div class=\"overlay grid-hover-content\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t<div class=\"post-right-content\">\n\t\t\t\t<div class=\"entry-title-wrapper\"><h3 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src=\"https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/05\/08102025-150x150.png\"\n\t\t\t\t\t\t\t class=\"rt-img-responsive\"\n\t\t\t\t\t\t\t width=\"150\"\n\t\t\t\t\t\t\t height=\"150\"\n\t\t\t\t\t\t\t alt=\"Read More, Write More: A Realistic Guide to Academic Writing\">\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t<\/a>\n\t\t\t\t<div class=\"overlay grid-hover-content\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t<div class=\"post-right-content\">\n\t\t\t\t<div class=\"entry-title-wrapper\"><h3 class=\"entry-title\"><a data-id=\"1329\" href=\"https:\/\/scisoup.org\/in\/2025\/10\/08\/read-more-write-more-a-realistic-guide-to-academic-writing\/\" class=\"tpg-post-link\" target=\"_self\">Read More, Write More: A Realistic Guide to Academic Writing<\/a><\/h3><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"post-meta-tags rt-el-post-meta\">\n\t\t\t\t\t\t\t\t\t<span class=\"date\">\n\t\t\t\t<i class=\"tpg-flaticon-calendar \"><\/i>\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/scisoup.org\/in\/2025\/10\/08\/\">\n\t\t\t\t\tOctober 8, 2025\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"categories-links\">\n\t\t\t\t<i class=\"tpg-flaticon-folder \"><\/i><a class=\"articles\" href=\"https:\/\/scisoup.org\/in\/category\/articles\/\">Articles<\/a><span class=\"rt-separator\">,<\/span><a class=\"career-insights\" href=\"https:\/\/scisoup.org\/in\/category\/career-insights\/\">Career Insights<\/a>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div class=\"rt-col-md-12 rt-col-sm-12 rt-col-xs-12 default rt-list-item rt-grid-item\" data-id=\"1339\">\n\t<div class=\"rt-holder tpg-post-holder \">\n\t\t<div class=\"rt-detail rt-el-content-wrapper\">\n\t\t\t\t\t\t\t<div class=\"rt-img-holder tpg-el-image-wrap has-thumbnail\">\n\t\t\t\t\t<a data-id=\"1339\" href=\"https:\/\/scisoup.org\/in\/2025\/09\/03\/plants-rebuild-roots-using-geometry-not-just-genes-study\/\" class=\"tpg-post-link\" target=\"_self\">\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/03\/03092025-150x150.png\"\n\t\t\t\t\t\t\t class=\"rt-img-responsive\"\n\t\t\t\t\t\t\t width=\"150\"\n\t\t\t\t\t\t\t height=\"150\"\n\t\t\t\t\t\t\t alt=\"Plants Rebuild Roots Using Geometry, Not Just Genes: Study\">\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t<\/a>\n\t\t\t\t<div class=\"overlay grid-hover-content\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t<div class=\"post-right-content\">\n\t\t\t\t<div class=\"entry-title-wrapper\"><h3 class=\"entry-title\"><a data-id=\"1339\" href=\"https:\/\/scisoup.org\/in\/2025\/09\/03\/plants-rebuild-roots-using-geometry-not-just-genes-study\/\" class=\"tpg-post-link\" target=\"_self\">Plants Rebuild Roots Using Geometry, Not Just Genes: Study<\/a><\/h3><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"post-meta-tags rt-el-post-meta\">\n\t\t\t\t\t\t\t\t\t<span class=\"date\">\n\t\t\t\t<i class=\"tpg-flaticon-calendar \"><\/i>\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/scisoup.org\/in\/2025\/09\/03\/\">\n\t\t\t\t\tSeptember 3, 2025\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"categories-links\">\n\t\t\t\t<i class=\"tpg-flaticon-folder \"><\/i><a class=\"articles\" href=\"https:\/\/scisoup.org\/in\/category\/articles\/\">Articles<\/a><span class=\"rt-separator\">,<\/span><a class=\"latest\" href=\"https:\/\/scisoup.org\/in\/category\/latest\/\">Latest<\/a><span class=\"rt-separator\">,<\/span><a class=\"recent-posts\" href=\"https:\/\/scisoup.org\/in\/category\/recent-posts\/\">Recent Posts<\/a>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div class=\"rt-col-md-12 rt-col-sm-12 rt-col-xs-12 default rt-list-item rt-grid-item\" data-id=\"1321\">\n\t<div class=\"rt-holder tpg-post-holder \">\n\t\t<div class=\"rt-detail rt-el-content-wrapper\">\n\t\t\t\t\t\t\t<div class=\"rt-img-holder tpg-el-image-wrap has-thumbnail\">\n\t\t\t\t\t<a data-id=\"1321\" href=\"https:\/\/scisoup.org\/in\/2025\/05\/06\/scientists-uncover-unusual-cell-division-behind-glioblastomas-deadly-comeback-3\/\" class=\"tpg-post-link\" target=\"_self\">\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/01\/06052025-150x150.png\"\n\t\t\t\t\t\t\t class=\"rt-img-responsive\"\n\t\t\t\t\t\t\t width=\"150\"\n\t\t\t\t\t\t\t height=\"150\"\n\t\t\t\t\t\t\t alt=\"Scientists Uncover Unusual Cell Division Behind Glioblastoma\u2019s Deadly Comeback\">\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t<\/a>\n\t\t\t\t<div class=\"overlay grid-hover-content\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t<div class=\"post-right-content\">\n\t\t\t\t<div class=\"entry-title-wrapper\"><h3 class=\"entry-title\"><a data-id=\"1321\" href=\"https:\/\/scisoup.org\/in\/2025\/05\/06\/scientists-uncover-unusual-cell-division-behind-glioblastomas-deadly-comeback-3\/\" class=\"tpg-post-link\" target=\"_self\">Scientists Uncover Unusual Cell Division Behind Glioblastoma\u2019s Deadly Comeback<\/a><\/h3><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"post-meta-tags rt-el-post-meta\">\n\t\t\t\t\t\t\t\t\t<span class=\"date\">\n\t\t\t\t<i class=\"tpg-flaticon-calendar \"><\/i>\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/scisoup.org\/in\/2025\/05\/06\/\">\n\t\t\t\t\tMay 6, 2025\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"categories-links\">\n\t\t\t\t<i class=\"tpg-flaticon-folder \"><\/i><a class=\"articles\" href=\"https:\/\/scisoup.org\/in\/category\/articles\/\">Articles<\/a><span class=\"rt-separator\">,<\/span><a class=\"latest\" href=\"https:\/\/scisoup.org\/in\/category\/latest\/\">Latest<\/a><span class=\"rt-separator\">,<\/span><a class=\"recent-posts\" href=\"https:\/\/scisoup.org\/in\/category\/recent-posts\/\">Recent 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Undergraduates\">\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t<\/a>\n\t\t\t\t<div class=\"overlay grid-hover-content\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t<div class=\"post-right-content\">\n\t\t\t\t<div class=\"entry-title-wrapper\"><h3 class=\"entry-title\"><a data-id=\"1363\" href=\"https:\/\/scisoup.org\/in\/2025\/01\/14\/navigating-internships-and-research-opportunities-in-india-ten-faqs-for-undergraduates\/\" class=\"tpg-post-link\" target=\"_self\">Navigating Internships and Research Opportunities in India: Ten FAQs for Undergraduates<\/a><\/h3><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"post-meta-tags rt-el-post-meta\">\n\t\t\t\t\t\t\t\t\t<span class=\"date\">\n\t\t\t\t<i class=\"tpg-flaticon-calendar \"><\/i>\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/scisoup.org\/in\/2025\/01\/14\/\">\n\t\t\t\t\tJanuary 14, 2025\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"categories-links\">\n\t\t\t\t<i class=\"tpg-flaticon-folder \"><\/i><a class=\"articles\" href=\"https:\/\/scisoup.org\/in\/category\/articles\/\">Articles<\/a><span class=\"rt-separator\">,<\/span><a class=\"career-insights\" href=\"https:\/\/scisoup.org\/in\/category\/career-insights\/\">Career Insights<\/a><span class=\"rt-separator\">,<\/span><a class=\"recent-posts\" href=\"https:\/\/scisoup.org\/in\/category\/recent-posts\/\">Recent Posts<\/a><span class=\"rt-separator\">,<\/span><a class=\"spotlight\" href=\"https:\/\/scisoup.org\/in\/category\/spotlight\/\">Spotlight<\/a>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div class=\"rt-col-md-12 rt-col-sm-12 rt-col-xs-12 default rt-list-item rt-grid-item\" data-id=\"1358\">\n\t<div class=\"rt-holder tpg-post-holder \">\n\t\t<div class=\"rt-detail rt-el-content-wrapper\">\n\t\t\t\t\t\t\t<div class=\"rt-img-holder tpg-el-image-wrap has-thumbnail\">\n\t\t\t\t\t<a data-id=\"1358\" href=\"https:\/\/scisoup.org\/in\/2025\/01\/12\/scientists-discover-a-new-host-protein-that-could-halt-viral-replication\/\" class=\"tpg-post-link\" target=\"_self\">\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/05\/12-01-2025-150x150.png\"\n\t\t\t\t\t\t\t class=\"rt-img-responsive\"\n\t\t\t\t\t\t\t width=\"150\"\n\t\t\t\t\t\t\t height=\"150\"\n\t\t\t\t\t\t\t alt=\"Scientists Discover a New Host Protein That Could Halt Viral Replication\">\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t<\/a>\n\t\t\t\t<div class=\"overlay grid-hover-content\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t<div class=\"post-right-content\">\n\t\t\t\t<div class=\"entry-title-wrapper\"><h3 class=\"entry-title\"><a data-id=\"1358\" href=\"https:\/\/scisoup.org\/in\/2025\/01\/12\/scientists-discover-a-new-host-protein-that-could-halt-viral-replication\/\" class=\"tpg-post-link\" target=\"_self\">Scientists Discover a New Host Protein That Could Halt Viral Replication<\/a><\/h3><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"post-meta-tags rt-el-post-meta\">\n\t\t\t\t\t\t\t\t\t<span class=\"date\">\n\t\t\t\t<i class=\"tpg-flaticon-calendar \"><\/i>\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/scisoup.org\/in\/2025\/01\/12\/\">\n\t\t\t\t\tJanuary 12, 2025\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"categories-links\">\n\t\t\t\t<i class=\"tpg-flaticon-folder \"><\/i><a class=\"articles\" href=\"https:\/\/scisoup.org\/in\/category\/articles\/\">Articles<\/a><span class=\"rt-separator\">,<\/span><a class=\"latest\" href=\"https:\/\/scisoup.org\/in\/category\/latest\/\">Latest<\/a><span class=\"rt-separator\">,<\/span><a class=\"recent-posts\" href=\"https:\/\/scisoup.org\/in\/category\/recent-posts\/\">Recent Posts<\/a>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div class=\"rt-col-md-12 rt-col-sm-12 rt-col-xs-12 default rt-list-item rt-grid-item\" data-id=\"1369\">\n\t<div class=\"rt-holder tpg-post-holder \">\n\t\t<div class=\"rt-detail rt-el-content-wrapper\">\n\t\t\t\t\t\t\t<div class=\"rt-img-holder tpg-el-image-wrap has-thumbnail\">\n\t\t\t\t\t<a data-id=\"1369\" href=\"https:\/\/scisoup.org\/in\/2024\/11\/05\/how-a-common-enzyme-in-worms-could-hold-secrets-to-longevity-and-gut-health\/\" class=\"tpg-post-link\" target=\"_self\">\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/05\/Jogendersingh-150x150.png\"\n\t\t\t\t\t\t\t class=\"rt-img-responsive\"\n\t\t\t\t\t\t\t width=\"150\"\n\t\t\t\t\t\t\t height=\"150\"\n\t\t\t\t\t\t\t alt=\"How a Common Enzyme in Worms Could Hold Secrets to Longevity\u2014and Gut Health\">\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t<\/a>\n\t\t\t\t<div class=\"overlay grid-hover-content\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t<div class=\"post-right-content\">\n\t\t\t\t<div class=\"entry-title-wrapper\"><h3 class=\"entry-title\"><a 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class=\"overlay grid-hover-content\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t<div class=\"post-right-content\">\n\t\t\t\t<div class=\"entry-title-wrapper\"><h3 class=\"entry-title\"><a data-id=\"1450\" href=\"https:\/\/scisoup.org\/in\/2024\/07\/06\/tapping-earths-heat-indias-next-big-leap-in-clean-energy\/\" class=\"tpg-post-link\" target=\"_self\">Tapping Earth&#8217;s Heat: India\u2019s Next Big Leap In Clean Energy<\/a><\/h3><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"post-meta-tags rt-el-post-meta\">\n\t\t\t\t\t\t\t\t\t<span class=\"date\">\n\t\t\t\t<i class=\"tpg-flaticon-calendar \"><\/i>\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/scisoup.org\/in\/2024\/07\/06\/\">\n\t\t\t\t\tJuly 6, 2024\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"categories-links\">\n\t\t\t\t<i class=\"tpg-flaticon-folder \"><\/i><a class=\"articles\" href=\"https:\/\/scisoup.org\/in\/category\/articles\/\">Articles<\/a><span class=\"rt-separator\">,<\/span><a class=\"recent-posts\" 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