{"id":1773,"date":"2017-09-13T12:53:50","date_gmt":"2017-09-13T12:53:50","guid":{"rendered":"https:\/\/scisoup.org\/in\/?p=1773"},"modified":"2026-06-15T07:06:25","modified_gmt":"2026-06-15T07:06:25","slug":"indian-researchers-explored-how-an-embryo-implants-in-to-the-mothers-womb","status":"publish","type":"post","link":"https:\/\/scisoup.org\/in\/2017\/09\/13\/indian-researchers-explored-how-an-embryo-implants-in-to-the-mothers-womb\/","title":{"rendered":"Indian Researchers Explored How An Embryo Implants In To The Mother\u2019s Womb"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"1773\" class=\"elementor elementor-1773\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2a31b5b5 e-flex e-con-boxed e-con e-parent\" data-id=\"2a31b5b5\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div 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decoding=\"async\" width=\"1024\" height=\"614\" src=\"https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/06\/13-09-2017-1024x614.png\" class=\"attachment-large size-large wp-image-1774\" alt=\"\" srcset=\"https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/06\/13-09-2017-1024x614.png 1024w, https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/06\/13-09-2017-300x180.png 300w, https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/06\/13-09-2017-768x461.png 768w, https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/06\/13-09-2017.png 1250w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b1e5f6d elementor-widget elementor-widget-text-editor\" data-id=\"b1e5f6d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>RATNESHWAR THAKUR<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element 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class=\"elementor-icon elementor-social-icon elementor-social-icon-linkedin elementor-repeater-item-6fee99d\" href=\"https:\/\/www.linkedin.com\/in\/ratnesh-thakur\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-screen-only\">Linkedin<\/span>\n\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fab-linkedin\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg>\t\t\t\t\t<\/a>\n\t\t\t\t<\/span>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-32649d1c elementor-widget elementor-widget-heading\" data-id=\"32649d1c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">A new study suggests for the first time about the existence of cross-talk between the mother\u2019s womb and an embryo to initiate a pregnancy.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7c109179 elementor-widget elementor-widget-text-editor\" data-id=\"7c109179\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><b><strong>R<\/strong><\/b><span style=\"font-weight: 400;\">eproduction is fundamental to all life forms and in humans initiation of pregnancy requires the embryo to adhere in the mother\u2019s womb. As the embryo enters the mother\u2019s womb, it has to rapidly find a suitable place to attach and then invade to get nutrition. This marks the initiation of pregnancy in humans. How the embryo decides where to implant and how the mother prepares her womb to initiate pregnancy is unknown.<\/span><br style=\"font-weight: 400;\" \/><br style=\"font-weight: 400;\" \/><span style=\"font-weight: 400;\">In a collaborative effort, research teams led by Dr. Deepak Modi- Scientist at ICMR-National Institute for Research in Reproductive Health-Mumbai, Dr. Satish K. Gupta- Emeritus Scientist at National Institute of Immunology- New Delhi, and Dr. Asgerally Fazleabas, Professor at Michigan State University, USA- have shed light on how the mother prepares her womb to initiate pregnancy.<\/span><br style=\"font-weight: 400;\" \/><br style=\"font-weight: 400;\" \/><span style=\"font-weight: 400;\">The results of the study were published in the Journal Endocrinology.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1a963405 e-con-full e-flex e-con e-child\" data-id=\"1a963405\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-1690415b e-con-full e-flex e-con e-child\" data-id=\"1690415b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3e087eaa e-con-full e-flex e-con e-child\" data-id=\"3e087eaa\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-13a264a5 elementor-widget elementor-widget-text-editor\" data-id=\"13a264a5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"comment vl\"><div class=\"comment vl\"><div class=\"comment vl\">\u201cMy lab is working on to dissect the mechanisms by which the embryo and mother talk to each other to initiate the pregnancy. This is a joint team effort of three different laboratories. Here I would like to highlight that it\u2019s only by networking we can make major breakthroughs,\u201d said Dr. Modi.<\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1914f888 elementor-widget elementor-widget-text-editor\" data-id=\"1914f888\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The study is exciting as it has given some important insights in very early life events that happen inside the mother\u2019s womb. What makes the discovery remarkable is that researchers have uncovered the mechanism by which the mother\u2019s womb tells the embryo about where to implant to initiate the pregnancy.<br \/><br \/>According to this study, a protein called as HOXA10 present in the mother&#8217;s endometrial cells and another protein called STAT3 in the cells of the embryo (the trophoblast cells) talk to each other. Researchers have observed that the signals sent by HOXA10 from the endometrial cells are sensed by STAT3 in the embryo which makes the trophoblast cells invade into the endometrium to establish the pregnancy.<br \/><br \/>The study had been technically challenging as it is neither ethical nor clinically justifiable to collect human tissue at early stages of pregnancy. \u201cIn-vitro data (study in laboratory set-up) needs to be proven in any In-vivo system (study in living system). To overcome this challenge, we did our studies in monkeys (which are closer to humans). We were happy our data in the lab dish turned out to be true even in the womb of monkeys,\u201d said Dr. Geeta Godbole, the first author of this paper.<br \/><br \/>In the present form, the study is very fundamental where Dr. Modi and his team members are trying to explore secrets of nature. However, there are several long-term implications. Firstly, for infertile couples, the IVF (test tube baby) is the only treatment option, but the success rates of IVF are very low (less than 30%). \u201cWe feel that the results of our study in long term will help in devising strategies to improve success rates of IVF,\u201d said Dr. Modi.<br \/><br \/>\u201cIn converse, our data may help in devising drugs that would help in blocking pregnancy and hence may act as contraceptives. Although far-fetched, the process of trophoblast invasion is synonymous to cancer metastasis; it is possible that our study would help in devising a treatment to prevent metastasis in cancers,\u201d said the study leader about the other future perspectives of this finding.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-59fc1e23 elementor-widget elementor-widget-text-editor\" data-id=\"59fc1e23\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>Journal Reference:<\/strong><br \/><a href=\"https:\/\/academic.oup.com\/endo\/article\/158\/8\/2618\/3828770\" target=\"_blank\" rel=\"noopener\">Decrease in Expression of HOXA10 in the Decidua After Embryo Implantation Promotes Trophoblast Invasion<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4d71cbd5 elementor-widget elementor-widget-text-editor\" data-id=\"4d71cbd5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>Disclaimer:<\/strong><br \/>SciSoup claims no competing interest. To ensure accuracy and scientific relevance, this science blog has been reviewed by the research team involved in the study.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-66f3ccbf e-con-full e-flex e-con e-child\" data-id=\"66f3ccbf\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1f100a00 section-title-style-style2 title-three-line meta-visibility-show title_position_default title_hover_border_default img_hover_animation_default meta_position_default tpg-category-position-default grid-hover-overlay-type-always tpg-el-box-border-enable tpg-border-bottom-disable elementor-widget elementor-widget-tpg-list-layout\" data-id=\"1f100a00\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"tpg-list-layout.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n        <div class=\"rt-container-fluid rt-tpg-container 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src=\"https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/05\/08102025-150x150.png\"\n\t\t\t\t\t\t\t class=\"rt-img-responsive\"\n\t\t\t\t\t\t\t width=\"150\"\n\t\t\t\t\t\t\t height=\"150\"\n\t\t\t\t\t\t\t alt=\"Read More, Write More: A Realistic Guide to Academic Writing\">\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t<\/a>\n\t\t\t\t<div class=\"overlay grid-hover-content\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t<div class=\"post-right-content\">\n\t\t\t\t<div class=\"entry-title-wrapper\"><h3 class=\"entry-title\"><a data-id=\"1329\" href=\"https:\/\/scisoup.org\/in\/2025\/10\/08\/read-more-write-more-a-realistic-guide-to-academic-writing\/\" class=\"tpg-post-link\" target=\"_self\">Read More, Write More: A Realistic Guide to Academic Writing<\/a><\/h3><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"post-meta-tags rt-el-post-meta\">\n\t\t\t\t\t\t\t\t\t<span class=\"date\">\n\t\t\t\t<i class=\"tpg-flaticon-calendar \"><\/i>\t\t\t\t\t\t\t\t\t<a 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tpg-el-image-wrap has-thumbnail\">\n\t\t\t\t\t<a data-id=\"1321\" href=\"https:\/\/scisoup.org\/in\/2025\/05\/06\/scientists-uncover-unusual-cell-division-behind-glioblastomas-deadly-comeback-3\/\" class=\"tpg-post-link\" target=\"_self\">\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/01\/06052025-150x150.png\"\n\t\t\t\t\t\t\t class=\"rt-img-responsive\"\n\t\t\t\t\t\t\t width=\"150\"\n\t\t\t\t\t\t\t height=\"150\"\n\t\t\t\t\t\t\t alt=\"Scientists Uncover Unusual Cell Division Behind Glioblastoma\u2019s Deadly Comeback\">\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t<\/a>\n\t\t\t\t<div class=\"overlay grid-hover-content\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t<div class=\"post-right-content\">\n\t\t\t\t<div class=\"entry-title-wrapper\"><h3 class=\"entry-title\"><a data-id=\"1321\" href=\"https:\/\/scisoup.org\/in\/2025\/05\/06\/scientists-uncover-unusual-cell-division-behind-glioblastomas-deadly-comeback-3\/\" 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Undergraduates\">\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t<\/a>\n\t\t\t\t<div class=\"overlay grid-hover-content\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t<div class=\"post-right-content\">\n\t\t\t\t<div class=\"entry-title-wrapper\"><h3 class=\"entry-title\"><a data-id=\"1363\" href=\"https:\/\/scisoup.org\/in\/2025\/01\/14\/navigating-internships-and-research-opportunities-in-india-ten-faqs-for-undergraduates\/\" class=\"tpg-post-link\" target=\"_self\">Navigating Internships and Research Opportunities in India: Ten FAQs for Undergraduates<\/a><\/h3><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"post-meta-tags rt-el-post-meta\">\n\t\t\t\t\t\t\t\t\t<span class=\"date\">\n\t\t\t\t<i class=\"tpg-flaticon-calendar \"><\/i>\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/scisoup.org\/in\/2025\/01\/14\/\">\n\t\t\t\t\tJanuary 14, 2025\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"categories-links\">\n\t\t\t\t<i class=\"tpg-flaticon-folder \"><\/i><a class=\"articles\" href=\"https:\/\/scisoup.org\/in\/category\/articles\/\">Articles<\/a><span class=\"rt-separator\">,<\/span><a class=\"career-insights\" href=\"https:\/\/scisoup.org\/in\/category\/career-insights\/\">Career Insights<\/a><span class=\"rt-separator\">,<\/span><a class=\"recent-posts\" href=\"https:\/\/scisoup.org\/in\/category\/recent-posts\/\">Recent Posts<\/a><span class=\"rt-separator\">,<\/span><a class=\"spotlight\" href=\"https:\/\/scisoup.org\/in\/category\/spotlight\/\">Spotlight<\/a>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div class=\"rt-col-md-12 rt-col-sm-12 rt-col-xs-12 default rt-list-item rt-grid-item\" data-id=\"1358\">\n\t<div class=\"rt-holder tpg-post-holder \">\n\t\t<div class=\"rt-detail rt-el-content-wrapper\">\n\t\t\t\t\t\t\t<div class=\"rt-img-holder tpg-el-image-wrap has-thumbnail\">\n\t\t\t\t\t<a data-id=\"1358\" href=\"https:\/\/scisoup.org\/in\/2025\/01\/12\/scientists-discover-a-new-host-protein-that-could-halt-viral-replication\/\" class=\"tpg-post-link\" target=\"_self\">\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/05\/12-01-2025-150x150.png\"\n\t\t\t\t\t\t\t class=\"rt-img-responsive\"\n\t\t\t\t\t\t\t width=\"150\"\n\t\t\t\t\t\t\t height=\"150\"\n\t\t\t\t\t\t\t alt=\"Scientists Discover a New Host Protein That Could Halt Viral Replication\">\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t<\/a>\n\t\t\t\t<div class=\"overlay grid-hover-content\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t<div class=\"post-right-content\">\n\t\t\t\t<div class=\"entry-title-wrapper\"><h3 class=\"entry-title\"><a data-id=\"1358\" href=\"https:\/\/scisoup.org\/in\/2025\/01\/12\/scientists-discover-a-new-host-protein-that-could-halt-viral-replication\/\" class=\"tpg-post-link\" target=\"_self\">Scientists Discover a New Host Protein That Could Halt Viral 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class=\"rt-holder tpg-post-holder \">\n\t\t<div class=\"rt-detail rt-el-content-wrapper\">\n\t\t\t\t\t\t\t<div class=\"rt-img-holder tpg-el-image-wrap has-thumbnail\">\n\t\t\t\t\t<a data-id=\"1377\" href=\"https:\/\/scisoup.org\/in\/2024\/08\/31\/commemorating-dr-ramalingaswami-the-fellowship-empowering-indian-scientists-2\/\" class=\"tpg-post-link\" target=\"_self\">\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/05\/31-08-2024-150x150.png\"\n\t\t\t\t\t\t\t class=\"rt-img-responsive\"\n\t\t\t\t\t\t\t width=\"150\"\n\t\t\t\t\t\t\t height=\"150\"\n\t\t\t\t\t\t\t alt=\"Commemorating Dr. Ramalingaswami: The Fellowship Empowering Indian Scientists\">\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t<\/a>\n\t\t\t\t<div class=\"overlay grid-hover-content\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t<div class=\"post-right-content\">\n\t\t\t\t<div class=\"entry-title-wrapper\"><h3 class=\"entry-title\"><a data-id=\"1377\" 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class=\"overlay grid-hover-content\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t<div class=\"post-right-content\">\n\t\t\t\t<div class=\"entry-title-wrapper\"><h3 class=\"entry-title\"><a data-id=\"1450\" href=\"https:\/\/scisoup.org\/in\/2024\/07\/06\/tapping-earths-heat-indias-next-big-leap-in-clean-energy\/\" class=\"tpg-post-link\" target=\"_self\">Tapping Earth&#8217;s Heat: India\u2019s Next Big Leap In Clean Energy<\/a><\/h3><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"post-meta-tags rt-el-post-meta\">\n\t\t\t\t\t\t\t\t\t<span class=\"date\">\n\t\t\t\t<i class=\"tpg-flaticon-calendar \"><\/i>\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/scisoup.org\/in\/2024\/07\/06\/\">\n\t\t\t\t\tJuly 6, 2024\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"categories-links\">\n\t\t\t\t<i class=\"tpg-flaticon-folder \"><\/i><a class=\"articles\" href=\"https:\/\/scisoup.org\/in\/category\/articles\/\">Articles<\/a><span class=\"rt-separator\">,<\/span><a class=\"recent-posts\" 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