{"id":1768,"date":"2017-09-21T12:47:49","date_gmt":"2017-09-21T12:47:49","guid":{"rendered":"https:\/\/scisoup.org\/in\/?p=1768"},"modified":"2026-06-15T07:06:18","modified_gmt":"2026-06-15T07:06:18","slug":"scientists-are-learning-lessons-of-regeneration-from-tiny-organism","status":"publish","type":"post","link":"https:\/\/scisoup.org\/in\/2017\/09\/21\/scientists-are-learning-lessons-of-regeneration-from-tiny-organism\/","title":{"rendered":"Scientists Are Learning Lessons Of Regeneration From Tiny Organism"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"1768\" class=\"elementor elementor-1768\">\n\t\t\t\t<div class=\"elementor-element elementor-element-441fc8fc e-flex e-con-boxed e-con e-parent\" data-id=\"441fc8fc\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-6640c0ed e-con-full e-flex e-con e-child\" data-id=\"6640c0ed\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-65ba9ea7 elementor-widget elementor-widget-sina_post_title\" data-id=\"65ba9ea7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"sina_post_title.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h2 class=\"sina-post-title\">Scientists Are Learning Lessons Of Regeneration From Tiny Organism<\/h2><!-- .sina-post-title -->\r\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-783de4f1 e-grid e-con-full e-con e-child\" data-id=\"783de4f1\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-4faafd03 e-con-full e-flex e-con e-child\" data-id=\"4faafd03\" 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data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">The study opens up a new possibility to discover the role of non-stem cells in the skin regeneration.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-146b6d07 elementor-widget elementor-widget-text-editor\" data-id=\"146b6d07\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><b><strong>I<\/strong><\/b><span style=\"font-weight: 400;\">n an ideal world, one would like to live with no deformities. How often you think about being able to re-grow limbs after an amputation or any injury. Imagine being able to regenerate your spinal cord after an accident has left you paralyzed. Nature has many examples of some tiny organisms completely re-growing from their small pieces. Scientists are studying such organisms to learn important lessons in regeneration.<\/span><br style=\"font-weight: 400;\" \/><br style=\"font-weight: 400;\" \/><span style=\"font-weight: 400;\">Researchers at the Bangalore-based Institute for Stem Cell Biology and Regenerative Medicine have reported that deformities in the epidermis of an organism called planaria cause the defect in their stem cell function and regeneration. This is significant because epidermal cells are not stem cells.<\/span><br style=\"font-weight: 400;\" \/><br style=\"font-weight: 400;\" \/><span style=\"font-weight: 400;\">Planaria are flatworms that live in fresh water and have the ability to regenerate from almost any pieces to form a completely new animal with all functional organ systems. Researchers used planaria as a model organism to understand the mechanism behind its immense regenerative ability.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-23ef2a24 e-con-full e-flex e-con e-child\" data-id=\"23ef2a24\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-1b0b7265 e-con-full e-flex e-con e-child\" data-id=\"1b0b7265\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-799a60 e-con-full e-flex e-con e-child\" data-id=\"799a60\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-27b7337c elementor-widget elementor-widget-text-editor\" data-id=\"27b7337c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<div class=\"comment vl\"><div class=\"comment vl\">\u201cOur study has shown how the organization of epidermal cells during planarian regeneration is crucial for regulating stem cell function,\u201d said Dr. Dasaradhi Palakodeti, a scientist at the Bangalore based Institute, and a co-author of the study published in the journal Development.<\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3297c3a8 elementor-widget elementor-widget-text-editor\" data-id=\"3297c3a8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Regeneration is often synonymous with stem cells and most of the studies focus on understanding factors essential for \u2018stemness\u2019. \u201cHere, for the first time we show how planarian epidermis (non- stem cell) plays a critical role in wound healing and stem cell function,\u201d said Dhiru Bansal, first author of this paper.<br \/><br \/>However, it is still unclear how the environment surrounding stem cells regulates their function. Researchers believe stem cells are instructed by surrounding cells to make right decisions to proliferate and differentiate for regeneration, to give rise missing tissues. The team is working to understand the role of a specific protein called PABPC2 (cytoplasmic poly A binding protein) in regeneration.<br \/><br \/>\u201cOur report about a crosstalk between stem cells and epidermis in planaria opens new possibilities that can be addressed in other systems as well,\u201d said Jahnavi Kulkarni, one of the authors of this paper.<br \/><br \/>The study opens up a new possibility to discover the role of non-stem cells in the skin regeneration. Skin is often well-thought-out for its protective function but this new study highlights other potential roles of the skin.<br \/><br \/>The research team included Dhiru Bansal, Jahnavi Kulkarni, Kavana Nadahalli, Vairavan Lakshmanan, Srikar Krishna, Vidyanand Sasidharan, Shilpa Dilipkumar, Akash Gulyani, Srikala Raghavan and Dasaradhi Palakodeti (Institute for Stem Cell Biology and Regenerative Medicine, Bangalore); Jini Geo and Renu Pasricha (National Centre for Biological Sciences, Bangalore).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-541b8b9 elementor-widget elementor-widget-text-editor\" data-id=\"541b8b9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>Journal Reference:<\/strong><br \/><a href=\"https:\/\/dev.biologists.org\/content\/144\/17\/3066\" target=\"_blank\" rel=\"noopener\">Cytoplasmic poly (A)-binding protein critically regulates epidermal maintenance and turnover in the planarian Schmidtea mediterranea<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5b797206 elementor-widget elementor-widget-text-editor\" data-id=\"5b797206\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>Disclaimer:<\/strong><br \/>SciSoup claims no competing interest. 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rt-grid-item\" data-id=\"1877\">\n\t<div class=\"rt-holder tpg-post-holder \">\n\t\t<div class=\"rt-detail rt-el-content-wrapper\">\n\t\t\t\t\t\t\t<div class=\"rt-img-holder tpg-el-image-wrap has-thumbnail\">\n\t\t\t\t\t<a data-id=\"1877\" href=\"https:\/\/scisoup.org\/in\/2026\/06\/13\/muscle-protein-helps-control-blood-sugar-revealing-new-link-to-diabetes\/\" class=\"tpg-post-link\" target=\"_self\">\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/06\/Sam-Mathew-Research-team-150x150.jpg\"\n\t\t\t\t\t\t\t class=\"rt-img-responsive\"\n\t\t\t\t\t\t\t width=\"150\"\n\t\t\t\t\t\t\t height=\"150\"\n\t\t\t\t\t\t\t alt=\"Muscle protein helps control blood sugar, revealing new link to diabetes\">\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t<\/a>\n\t\t\t\t<div class=\"overlay grid-hover-content\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t<div class=\"post-right-content\">\n\t\t\t\t<div class=\"entry-title-wrapper\"><h3 class=\"entry-title\"><a 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src=\"https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/05\/08102025-150x150.png\"\n\t\t\t\t\t\t\t class=\"rt-img-responsive\"\n\t\t\t\t\t\t\t width=\"150\"\n\t\t\t\t\t\t\t height=\"150\"\n\t\t\t\t\t\t\t alt=\"Read More, Write More: A Realistic Guide to Academic Writing\">\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t<\/a>\n\t\t\t\t<div class=\"overlay grid-hover-content\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t<div class=\"post-right-content\">\n\t\t\t\t<div class=\"entry-title-wrapper\"><h3 class=\"entry-title\"><a data-id=\"1329\" href=\"https:\/\/scisoup.org\/in\/2025\/10\/08\/read-more-write-more-a-realistic-guide-to-academic-writing\/\" class=\"tpg-post-link\" target=\"_self\">Read More, Write More: A Realistic Guide to Academic Writing<\/a><\/h3><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"post-meta-tags rt-el-post-meta\">\n\t\t\t\t\t\t\t\t\t<span class=\"date\">\n\t\t\t\t<i class=\"tpg-flaticon-calendar \"><\/i>\t\t\t\t\t\t\t\t\t<a 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class=\"tpg-post-link\" target=\"_self\">\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/03\/03092025-150x150.png\"\n\t\t\t\t\t\t\t class=\"rt-img-responsive\"\n\t\t\t\t\t\t\t width=\"150\"\n\t\t\t\t\t\t\t height=\"150\"\n\t\t\t\t\t\t\t alt=\"Plants Rebuild Roots Using Geometry, Not Just Genes: Study\">\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t<\/a>\n\t\t\t\t<div class=\"overlay grid-hover-content\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t<div class=\"post-right-content\">\n\t\t\t\t<div class=\"entry-title-wrapper\"><h3 class=\"entry-title\"><a data-id=\"1339\" href=\"https:\/\/scisoup.org\/in\/2025\/09\/03\/plants-rebuild-roots-using-geometry-not-just-genes-study\/\" class=\"tpg-post-link\" target=\"_self\">Plants Rebuild Roots Using Geometry, Not Just Genes: Study<\/a><\/h3><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"post-meta-tags rt-el-post-meta\">\n\t\t\t\t\t\t\t\t\t<span class=\"date\">\n\t\t\t\t<i 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tpg-el-image-wrap has-thumbnail\">\n\t\t\t\t\t<a data-id=\"1321\" href=\"https:\/\/scisoup.org\/in\/2025\/05\/06\/scientists-uncover-unusual-cell-division-behind-glioblastomas-deadly-comeback-3\/\" class=\"tpg-post-link\" target=\"_self\">\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/01\/06052025-150x150.png\"\n\t\t\t\t\t\t\t class=\"rt-img-responsive\"\n\t\t\t\t\t\t\t width=\"150\"\n\t\t\t\t\t\t\t height=\"150\"\n\t\t\t\t\t\t\t alt=\"Scientists Uncover Unusual Cell Division Behind Glioblastoma\u2019s Deadly Comeback\">\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t<\/a>\n\t\t\t\t<div class=\"overlay grid-hover-content\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t<div class=\"post-right-content\">\n\t\t\t\t<div class=\"entry-title-wrapper\"><h3 class=\"entry-title\"><a data-id=\"1321\" href=\"https:\/\/scisoup.org\/in\/2025\/05\/06\/scientists-uncover-unusual-cell-division-behind-glioblastomas-deadly-comeback-3\/\" class=\"tpg-post-link\" target=\"_self\">Scientists Uncover Unusual Cell Division Behind Glioblastoma\u2019s Deadly Comeback<\/a><\/h3><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"post-meta-tags rt-el-post-meta\">\n\t\t\t\t\t\t\t\t\t<span class=\"date\">\n\t\t\t\t<i class=\"tpg-flaticon-calendar \"><\/i>\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/scisoup.org\/in\/2025\/05\/06\/\">\n\t\t\t\t\tMay 6, 2025\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"categories-links\">\n\t\t\t\t<i class=\"tpg-flaticon-folder \"><\/i><a class=\"articles\" href=\"https:\/\/scisoup.org\/in\/category\/articles\/\">Articles<\/a><span class=\"rt-separator\">,<\/span><a class=\"latest\" href=\"https:\/\/scisoup.org\/in\/category\/latest\/\">Latest<\/a><span class=\"rt-separator\">,<\/span><a class=\"recent-posts\" href=\"https:\/\/scisoup.org\/in\/category\/recent-posts\/\">Recent 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Undergraduates\">\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t<\/a>\n\t\t\t\t<div class=\"overlay grid-hover-content\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t<div class=\"post-right-content\">\n\t\t\t\t<div class=\"entry-title-wrapper\"><h3 class=\"entry-title\"><a data-id=\"1363\" href=\"https:\/\/scisoup.org\/in\/2025\/01\/14\/navigating-internships-and-research-opportunities-in-india-ten-faqs-for-undergraduates\/\" class=\"tpg-post-link\" target=\"_self\">Navigating Internships and Research Opportunities in India: Ten FAQs for Undergraduates<\/a><\/h3><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"post-meta-tags rt-el-post-meta\">\n\t\t\t\t\t\t\t\t\t<span class=\"date\">\n\t\t\t\t<i class=\"tpg-flaticon-calendar \"><\/i>\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/scisoup.org\/in\/2025\/01\/14\/\">\n\t\t\t\t\tJanuary 14, 2025\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"categories-links\">\n\t\t\t\t<i class=\"tpg-flaticon-folder \"><\/i><a class=\"articles\" href=\"https:\/\/scisoup.org\/in\/category\/articles\/\">Articles<\/a><span class=\"rt-separator\">,<\/span><a class=\"career-insights\" href=\"https:\/\/scisoup.org\/in\/category\/career-insights\/\">Career Insights<\/a><span class=\"rt-separator\">,<\/span><a class=\"recent-posts\" href=\"https:\/\/scisoup.org\/in\/category\/recent-posts\/\">Recent Posts<\/a><span class=\"rt-separator\">,<\/span><a class=\"spotlight\" href=\"https:\/\/scisoup.org\/in\/category\/spotlight\/\">Spotlight<\/a>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div class=\"rt-col-md-12 rt-col-sm-12 rt-col-xs-12 default rt-list-item rt-grid-item\" data-id=\"1358\">\n\t<div class=\"rt-holder tpg-post-holder \">\n\t\t<div class=\"rt-detail rt-el-content-wrapper\">\n\t\t\t\t\t\t\t<div class=\"rt-img-holder tpg-el-image-wrap has-thumbnail\">\n\t\t\t\t\t<a data-id=\"1358\" href=\"https:\/\/scisoup.org\/in\/2025\/01\/12\/scientists-discover-a-new-host-protein-that-could-halt-viral-replication\/\" class=\"tpg-post-link\" target=\"_self\">\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/scisoup.org\/in\/wp-content\/uploads\/2026\/05\/12-01-2025-150x150.png\"\n\t\t\t\t\t\t\t class=\"rt-img-responsive\"\n\t\t\t\t\t\t\t width=\"150\"\n\t\t\t\t\t\t\t height=\"150\"\n\t\t\t\t\t\t\t alt=\"Scientists Discover a New Host Protein That Could Halt Viral Replication\">\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t<\/a>\n\t\t\t\t<div class=\"overlay grid-hover-content\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t<div class=\"post-right-content\">\n\t\t\t\t<div class=\"entry-title-wrapper\"><h3 class=\"entry-title\"><a data-id=\"1358\" href=\"https:\/\/scisoup.org\/in\/2025\/01\/12\/scientists-discover-a-new-host-protein-that-could-halt-viral-replication\/\" class=\"tpg-post-link\" target=\"_self\">Scientists Discover a New Host Protein That Could Halt Viral Replication<\/a><\/h3><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"post-meta-tags rt-el-post-meta\">\n\t\t\t\t\t\t\t\t\t<span class=\"date\">\n\t\t\t\t<i class=\"tpg-flaticon-calendar \"><\/i>\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/scisoup.org\/in\/2025\/01\/12\/\">\n\t\t\t\t\tJanuary 12, 2025\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"categories-links\">\n\t\t\t\t<i class=\"tpg-flaticon-folder \"><\/i><a class=\"articles\" href=\"https:\/\/scisoup.org\/in\/category\/articles\/\">Articles<\/a><span class=\"rt-separator\">,<\/span><a class=\"latest\" href=\"https:\/\/scisoup.org\/in\/category\/latest\/\">Latest<\/a><span class=\"rt-separator\">,<\/span><a class=\"recent-posts\" href=\"https:\/\/scisoup.org\/in\/category\/recent-posts\/\">Recent Posts<\/a>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div class=\"rt-col-md-12 rt-col-sm-12 rt-col-xs-12 default rt-list-item rt-grid-item\" 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class=\"overlay grid-hover-content\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t<div class=\"post-right-content\">\n\t\t\t\t<div class=\"entry-title-wrapper\"><h3 class=\"entry-title\"><a data-id=\"1450\" href=\"https:\/\/scisoup.org\/in\/2024\/07\/06\/tapping-earths-heat-indias-next-big-leap-in-clean-energy\/\" class=\"tpg-post-link\" target=\"_self\">Tapping Earth&#8217;s Heat: India\u2019s Next Big Leap In Clean Energy<\/a><\/h3><\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"post-meta-tags rt-el-post-meta\">\n\t\t\t\t\t\t\t\t\t<span class=\"date\">\n\t\t\t\t<i class=\"tpg-flaticon-calendar \"><\/i>\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/scisoup.org\/in\/2024\/07\/06\/\">\n\t\t\t\t\tJuly 6, 2024\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t<span class=\"categories-links\">\n\t\t\t\t<i class=\"tpg-flaticon-folder \"><\/i><a class=\"articles\" href=\"https:\/\/scisoup.org\/in\/category\/articles\/\">Articles<\/a><span class=\"rt-separator\">,<\/span><a class=\"recent-posts\" 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